シラバス参照

基本情報／Basic Information
詳細情報／Detailed Information
授業計画詳細情報／Class Schedule Details

基本情報/Basic Information

開講科目名／Course	分子機能化学
時間割コード／Course Code	8222000039
ターム・学期／Term・Semester	2022年度／Academic Year　　後期
曜日コマ／Day, Period	水／Wed　2
開講区分／Semester offered	後期／second semester
単位数／Credits	2.0
主担当教員／Main Instructor	橋本勝／HASHIMOTO MASARU
授業形式／Class Format	講義科目

担当教員情報/Instructor Information

教員名／Instructor	教員所属名／Faculty/Department
橋本勝／HASHIMOTO MASARU	農学生命科学部／

難易度（レベル）／Level	レベル3
対応するＣＰ／ＤＰ／CP/DP	CP・DP　１　見通す力　　 CP・DP　３　学び続ける力
授業としての具体的到達目標／Concrete arrival target as the class	〇Understand that the structure and reactivity of molecules are important for the function of biologically active molecules (the ability to see things through) 〇Learn, as a student of life science, the thoughts and emotions of the past great scientists who have devoted their lives to the development of pharmaceuticals (the ability to continue learning) 〇Understand, as a student of life science, the impact that pharmaceuticals have had on the history of humankind (the ability to continue learning)
授業の概要／Summary of the class	This lecture will discuss the functions of bioactive molecules, using drugs as examples. The background of the bioactive molecules will also be discussed.
授業の内容予定／Contents plan of the class	1. Outline and introduction of this lecture (how to proceed, evaluation, etc., drug-biomolecule interactions) 2. What are biologically active substances (differences between pharmaceuticals, agricultural chemicals, and functional foods)? 3. In search of magic bullet (1) (History of antibiotics and functions of sulfa drugs) 4. In search of magic bullet (2) (History of Penicillin and Mechanism of Action) 5. In search of the magic bullet (3) (The mechanism of antibiotic resistance and the evolution of antibiotics) 6. Fight against cancer (1) (turkey X disease, anticancer drugs as alkylating agents) 7. Fight against cancer (2) (imatinib, methotrexate, and Herceptin) 8. Viruses and Influenza (Influenza mechanism and Tamiflu and Relenza) 9. Fight against AIDS (zidovudine and Kaletra) 10. Lowering Blood Pressure (Renin Inhibitors and Angiotensin Converting Enzyme Inhibitors) 11. Anticoagulants, Diabetes Drugs (Argatroban and Insulin) 12. Cholesterol lowering (HMG-coA reductase inhibitors, statins and Lipitor) 13. Drugs for Immune and Inflammatory Responses (Tacrolimus, Aspirin and Prostaglandins) 14. Persistent search for H2 blocker (gastric ulcer drug cimetidine) 15. In Search of safer medicines (Drug Injury Case and Clinical Trials)
成績評価方法及び採点基準／A scholastic evaluation method and marking standard	Evaluation 1: (mini-report) 50%. Evaluation 2: (final report): 50%.
予習及び復習等の内容／Contents such as preparations for lessons and the review	Please read the textbook before the class. Students are required to submit a mini-report for each class. It is recommended to read the organic chemistry and biochemistry textbooks for confirmation. It will be helpful to use molecular modeling programs such as RASMOL to confirm the 3D structure of the bioactive molecules used in the lecture.
教材・教科書／The teaching materials, textbook	by 平山令明カラー図解分子レベルで見た薬の働きなぜ効くのか? どのように病気を治すのか? 講談社ブルーバックス 2020.2.23
参考文献／bibliography
留意点・予備知識／Point to keep in mind, back ground	Students should have a certain level of knowledge of biochemistry and organic chemistry. Please prepare the textbooks used in the biochemistry and organic chemistry classes as reference books.
授業内容に関する質問・疑義等／Question, doubt about class contents	Monday 12:00-14:00
Eメールアドレス・HPアドレス／E-mail address, HP address	e-mail:hmasaru[at]hirosaki-u.ac.jp home page URL: http://nature.cc.hirosaki-u.ac.jp/lab/2/biochem/yuki/ Please replace [at] into @
学問分野1（主学問分野）／Discipline 1	E33:有機化学およびその関連分野
学問分野2（副学問分野）／Discipline 2	G43:分子レベルから細胞レベルの生物学およびその関連分野
学問分野3（副学問分野）／Discipline 3	H47:薬学およびその関連分野
実務経験のある教員による授業科目について／About the class subject by the teacher with the work experience	実務経験
地域志向科目／Local intention subject	なし
授業形態・授業方法／Class form, class method	The lecture will be conducted using PowePoint.
科目ナンバー／The subject number
メディア授業による著作物利用の有無について／Whether or not copyrighted works are used in media classes	無／Nothing
その他／Others	Faculty with practical experience (researcher in an institute) will be in charge.

No.	回（日時）／Time (date and time)	主題と位置付け（担当）／Subjects and instructor's position	学習方法と内容／Methods and contents	備考／Notes
該当するデータはありません

難易度（レベル）／Level	レベル3
対応するＣＰ／ＤＰ／CP/DP	CP・DP　１　見通す力　　 CP・DP　３　学び続ける力
授業としての具体的到達目標／Concrete arrival target as the class	〇Understand that the structure and reactivity of molecules are important for the function of biologically active molecules (the ability to see things through) 〇Learn, as a student of life science, the thoughts and emotions of the past great scientists who have devoted their lives to the development of pharmaceuticals (the ability to continue learning) 〇Understand, as a student of life science, the impact that pharmaceuticals have had on the history of humankind (the ability to continue learning)
授業の概要／Summary of the class	This lecture will discuss the functions of bioactive molecules, using drugs as examples. The background of the bioactive molecules will also be discussed.
授業の内容予定／Contents plan of the class	1. Outline and introduction of this lecture (how to proceed, evaluation, etc., drug-biomolecule interactions) 2. What are biologically active substances (differences between pharmaceuticals, agricultural chemicals, and functional foods)? 3. In search of magic bullet (1) (History of antibiotics and functions of sulfa drugs) 4. In search of magic bullet (2) (History of Penicillin and Mechanism of Action) 5. In search of the magic bullet (3) (The mechanism of antibiotic resistance and the evolution of antibiotics) 6. Fight against cancer (1) (turkey X disease, anticancer drugs as alkylating agents) 7. Fight against cancer (2) (imatinib, methotrexate, and Herceptin) 8. Viruses and Influenza (Influenza mechanism and Tamiflu and Relenza) 9. Fight against AIDS (zidovudine and Kaletra) 10. Lowering Blood Pressure (Renin Inhibitors and Angiotensin Converting Enzyme Inhibitors) 11. Anticoagulants, Diabetes Drugs (Argatroban and Insulin) 12. Cholesterol lowering (HMG-coA reductase inhibitors, statins and Lipitor) 13. Drugs for Immune and Inflammatory Responses (Tacrolimus, Aspirin and Prostaglandins) 14. Persistent search for H2 blocker (gastric ulcer drug cimetidine) 15. In Search of safer medicines (Drug Injury Case and Clinical Trials)
成績評価方法及び採点基準／A scholastic evaluation method and marking standard	Evaluation 1: (mini-report) 50%. Evaluation 2: (final report): 50%.
予習及び復習等の内容／Contents such as preparations for lessons and the review	Please read the textbook before the class. Students are required to submit a mini-report for each class. It is recommended to read the organic chemistry and biochemistry textbooks for confirmation. It will be helpful to use molecular modeling programs such as RASMOL to confirm the 3D structure of the bioactive molecules used in the lecture.
教材・教科書／The teaching materials, textbook	by 平山令明カラー図解分子レベルで見た薬の働きなぜ効くのか? どのように病気を治すのか? 講談社ブルーバックス 2020.2.23
参考文献／bibliography
留意点・予備知識／Point to keep in mind, back ground	Students should have a certain level of knowledge of biochemistry and organic chemistry. Please prepare the textbooks used in the biochemistry and organic chemistry classes as reference books.
授業内容に関する質問・疑義等／Question, doubt about class contents	Monday 12:00-14:00
Eメールアドレス・HPアドレス／E-mail address, HP address	e-mail:hmasaru[at]hirosaki-u.ac.jp home page URL: http://nature.cc.hirosaki-u.ac.jp/lab/2/biochem/yuki/ Please replace [at] into @
学問分野1（主学問分野）／Discipline 1	E33:有機化学およびその関連分野
学問分野2（副学問分野）／Discipline 2	G43:分子レベルから細胞レベルの生物学およびその関連分野
学問分野3（副学問分野）／Discipline 3	H47:薬学およびその関連分野
実務経験のある教員による授業科目について／About the class subject by the teacher with the work experience	実務経験
地域志向科目／Local intention subject	なし
授業形態・授業方法／Class form, class method	The lecture will be conducted using PowePoint.
科目ナンバー／The subject number
メディア授業による著作物利用の有無について／Whether or not copyrighted works are used in media classes	無／Nothing
その他／Others	Faculty with practical experience (researcher in an institute) will be in charge.

授業情報／Class Information

基本情報/Basic Information

担当教員情報/Instructor Information