シラバス参照

基本情報／Basic Information
詳細情報／Detailed Information
授業計画詳細情報／Class Schedule Details

基本情報/Basic Information

開講科目名／Course	酵素化学／Enzyme Chemistry
時間割コード／Course Code	8241000039
ターム・学期／Term・Semester	2024年度／Academic Year　　前期
曜日コマ／Day, Period	他
開講区分／Semester offered	前期／first semester
単位数／Credits	2.0
主担当教員／Main Instructor	吉田孝／YOSHIDA TAKASHI
授業形式／Class Format	講義科目

担当教員情報/Instructor Information

教員名／Instructor	教員所属名／Faculty/Department
吉田孝／YOSHIDA TAKASHI	農学生命科学部／

難易度（レベル）／Level	レベル2
対応するＣＰ／ＤＰ／CP/DP	CP・DP　１　見通す力
授業としての具体的到達目標／Concrete arrival target as the class	The goal is to have basic knowledge of the following items (ability to see through). 〇Characteristics of enzymes as biocatalysts 〇Enzyme classification (meaning of EC number) 〇Inhibition and control of enzyme reactions 〇Role of enzymes in living organisms 〇Biotechnology using enzymes
授業の概要／Summary of the class	Enzymes are catalysts created by living organisms to speed up chemical reactions in nature. Enzymology, which began with the idea that food dissolves in the stomach, has now spread to the fields of biology, pharmacy, medicine, and agriculture based on physics and chemistry. Without knowledge of enzymes, it is difficult to have a deeper understanding of life phenomena and biotechnology. This lecture will focus on enzyme reaction theory and various topics in medicine, food, medicine, and engineering, and will cover basic knowledge at the molecular level, roles in living organisms, and applications to human life and industry.
授業の内容予定／Contents plan of the class	This class is an intensive lecture. 【Part 1】 1. Classification of enzymes: 7 groups classification method 2. Classification of enzymes: Specifics ① 3. Classification of enzymes: Specifics ② 4. Classification of enzymes: Specifics ③ 5. Summary and review [Part 2] 6. Enzyme reaction kinetics: Michaelis constant and maximum reaction rate 7. Competitive inhibition 8. Non-competitive inhibition 9. Control of enzyme activity (1) Proenzymes and digestive enzymes - the dilemma of too strong enzymes 10. Control of enzyme activity (2) Phosphorylation of phosphorylase - Ladder reaction with widening at the end 11. Summary and review [Part 3] 12. Allosterism and allosteric enzymes 13. Biotechnology using enzymes (1) 14. Biotechnology using enzymes (2) 15. General supplements 16. Summary and review
成績評価方法及び採点基準／A scholastic evaluation method and marking standard	At the end of Parts 1, 2, and 3, there will be a summary and review. The answers to these questions will be evaluated as 100%. Details will be explained in class. (Please note that due to circumstances related to coronavirus infection and prevention, the exam may be conducted remotely. In that case, the exam will be conducted using Teams and Forms, but details will be communicated in advance.) .)
予習及び復習等の内容／Contents such as preparations for lessons and the review	[Preparation] Understand the basics of organic chemistry, the types of amino acids (20 types) and their notation, and the structures of carbohydrates and proteins. Also, knowledge about the glycolytic pathway is very important. Please use the following website for preparation. Enzyme Nomenclature (https://www.qmul.ac.uk/sbcs/iubmb/enzyme/) EXPASY enzyme (https://enzyme.expasy.org/) BRENDA (https://www.brenda-enzymes.org/) METACYC (https://metacyc.org/) [Review] Organize and save your prints. Carefully review handouts and notes, and revise them if necessary. Organize and understand the main points (keywords) covered in that day's class.
教材・教科書／The teaching materials, textbook	〇We do not use specific books as textbooks. 〇 Materials will be distributed as needed during each class. Distribution of distributed materials to others via the web, email, or other electronic media is strictly prohibited. 〇I may use passages related to enzymes from Vought's ``Basic Biochemistry, 5th Edition''. 〇We may refer to the following web sites. Enzyme Nomenclature (https://www.qmul.ac.uk/sbcs/iubmb/enzyme/) EXPASY enzyme (https://enzyme.expasy.org/) BRENDA (https://www.brenda-enzymes.org/) METACYC (https://metacyc.org/) CAZY (http://www.cazy.org/)
参考文献／bibliography	We recommend the following books as reference books to deepen your understanding. “Learn about enzyme science from now on” edited by Toru Nakayama, Sankyo Publishing (ISBN978-4-7827-0785-2) "Chemistry of Enzymes" Eiji Ichishima Asakura Shoten (ISBN978-4-254-14555-7) "Enzyme Technology" Takayuki Ueshima Sachi Shobo (ISBN4-7821-Ol69-4) A Japanese review on the applications of enzymes can also be found at the following web site: https://www.jstage.jst.go.jp/browse/bag/6/0/_contents/-char/ja
留意点・予備知識／Point to keep in mind, back ground	〇The content of this class is deeply related to biochemistry I/II, applied microbiology, glycoengineering, etc. Talking about inhibition is also helpful in understanding pharmacological topics. 〇English is often used to express technical terms. 〇Forms will be used for attendance and assignments. We also plan to use Teams to distribute and collect such information, to communicate about classes, and to distribute materials used in classes. Please install Teams as an app on your own device. Also, if you are transitioning to remote classes to prevent coronavirus infection, please prepare an internet environment such as Wifi.
授業内容に関する質問・疑義等／Question, doubt about class contents	〇You may use Teams chat for individual questions and answers.
Eメールアドレス・HPアドレス／E-mail address, HP address	Email address: ytakashi [at] hirosaki-u.ac.jp Please replace [at] with @.
学問分野1（主学問分野）／Discipline 1	F38:農芸化学およびその関連分野
学問分野2（副学問分野）／Discipline 2	E37:生体分子化学およびその関連分野
学問分野3（副学問分野）／Discipline 3	G43:分子レベルから細胞レベルの生物学およびその関連分野
実務経験のある教員による授業科目について／About the class subject by the teacher with the work experience	なし
地域志向科目／Local intention subject	なし
授業形態・授業方法／Class form, class method	〇 This class is an intensive lecture. 〇Basically lecture format. 〇I plan to use Teams for distribution of Forms, other class-related communications, and individual questions and answers. 〇In case of transition to a media class, it will be held on Teams.
科目ナンバー／The subject number
メディア授業による著作物利用の有無について／Whether or not copyrighted works are used in media classes	有／Yes
その他／Others	〇I will use Teams to communicate with you regarding classes, so please install the app. 〇For registration on Teams, please contact Faculty Educational Secretariat. 〇Recording of classes is prohibited.

No.	回（日時）／Time (date and time)	主題と位置付け（担当）／Subjects and instructor's position	学習方法と内容／Methods and contents	備考／Notes
該当するデータはありません

難易度（レベル）／Level	レベル2
対応するＣＰ／ＤＰ／CP/DP	CP・DP　１　見通す力
授業としての具体的到達目標／Concrete arrival target as the class	The goal is to have basic knowledge of the following items (ability to see through). 〇Characteristics of enzymes as biocatalysts 〇Enzyme classification (meaning of EC number) 〇Inhibition and control of enzyme reactions 〇Role of enzymes in living organisms 〇Biotechnology using enzymes
授業の概要／Summary of the class	Enzymes are catalysts created by living organisms to speed up chemical reactions in nature. Enzymology, which began with the idea that food dissolves in the stomach, has now spread to the fields of biology, pharmacy, medicine, and agriculture based on physics and chemistry. Without knowledge of enzymes, it is difficult to have a deeper understanding of life phenomena and biotechnology. This lecture will focus on enzyme reaction theory and various topics in medicine, food, medicine, and engineering, and will cover basic knowledge at the molecular level, roles in living organisms, and applications to human life and industry.
授業の内容予定／Contents plan of the class	This class is an intensive lecture. 【Part 1】 1. Classification of enzymes: 7 groups classification method 2. Classification of enzymes: Specifics ① 3. Classification of enzymes: Specifics ② 4. Classification of enzymes: Specifics ③ 5. Summary and review [Part 2] 6. Enzyme reaction kinetics: Michaelis constant and maximum reaction rate 7. Competitive inhibition 8. Non-competitive inhibition 9. Control of enzyme activity (1) Proenzymes and digestive enzymes - the dilemma of too strong enzymes 10. Control of enzyme activity (2) Phosphorylation of phosphorylase - Ladder reaction with widening at the end 11. Summary and review [Part 3] 12. Allosterism and allosteric enzymes 13. Biotechnology using enzymes (1) 14. Biotechnology using enzymes (2) 15. General supplements 16. Summary and review
成績評価方法及び採点基準／A scholastic evaluation method and marking standard	At the end of Parts 1, 2, and 3, there will be a summary and review. The answers to these questions will be evaluated as 100%. Details will be explained in class. (Please note that due to circumstances related to coronavirus infection and prevention, the exam may be conducted remotely. In that case, the exam will be conducted using Teams and Forms, but details will be communicated in advance.) .)
予習及び復習等の内容／Contents such as preparations for lessons and the review	[Preparation] Understand the basics of organic chemistry, the types of amino acids (20 types) and their notation, and the structures of carbohydrates and proteins. Also, knowledge about the glycolytic pathway is very important. Please use the following website for preparation. Enzyme Nomenclature (https://www.qmul.ac.uk/sbcs/iubmb/enzyme/) EXPASY enzyme (https://enzyme.expasy.org/) BRENDA (https://www.brenda-enzymes.org/) METACYC (https://metacyc.org/) [Review] Organize and save your prints. Carefully review handouts and notes, and revise them if necessary. Organize and understand the main points (keywords) covered in that day's class.
教材・教科書／The teaching materials, textbook	〇We do not use specific books as textbooks. 〇 Materials will be distributed as needed during each class. Distribution of distributed materials to others via the web, email, or other electronic media is strictly prohibited. 〇I may use passages related to enzymes from Vought's ``Basic Biochemistry, 5th Edition''. 〇We may refer to the following web sites. Enzyme Nomenclature (https://www.qmul.ac.uk/sbcs/iubmb/enzyme/) EXPASY enzyme (https://enzyme.expasy.org/) BRENDA (https://www.brenda-enzymes.org/) METACYC (https://metacyc.org/) CAZY (http://www.cazy.org/)
参考文献／bibliography	We recommend the following books as reference books to deepen your understanding. “Learn about enzyme science from now on” edited by Toru Nakayama, Sankyo Publishing (ISBN978-4-7827-0785-2) "Chemistry of Enzymes" Eiji Ichishima Asakura Shoten (ISBN978-4-254-14555-7) "Enzyme Technology" Takayuki Ueshima Sachi Shobo (ISBN4-7821-Ol69-4) A Japanese review on the applications of enzymes can also be found at the following web site: https://www.jstage.jst.go.jp/browse/bag/6/0/_contents/-char/ja
留意点・予備知識／Point to keep in mind, back ground	〇The content of this class is deeply related to biochemistry I/II, applied microbiology, glycoengineering, etc. Talking about inhibition is also helpful in understanding pharmacological topics. 〇English is often used to express technical terms. 〇Forms will be used for attendance and assignments. We also plan to use Teams to distribute and collect such information, to communicate about classes, and to distribute materials used in classes. Please install Teams as an app on your own device. Also, if you are transitioning to remote classes to prevent coronavirus infection, please prepare an internet environment such as Wifi.
授業内容に関する質問・疑義等／Question, doubt about class contents	〇You may use Teams chat for individual questions and answers.
Eメールアドレス・HPアドレス／E-mail address, HP address	Email address: ytakashi [at] hirosaki-u.ac.jp Please replace [at] with @.
学問分野1（主学問分野）／Discipline 1	F38:農芸化学およびその関連分野
学問分野2（副学問分野）／Discipline 2	E37:生体分子化学およびその関連分野
学問分野3（副学問分野）／Discipline 3	G43:分子レベルから細胞レベルの生物学およびその関連分野
実務経験のある教員による授業科目について／About the class subject by the teacher with the work experience	なし
地域志向科目／Local intention subject	なし
授業形態・授業方法／Class form, class method	〇 This class is an intensive lecture. 〇Basically lecture format. 〇I plan to use Teams for distribution of Forms, other class-related communications, and individual questions and answers. 〇In case of transition to a media class, it will be held on Teams.
科目ナンバー／The subject number
メディア授業による著作物利用の有無について／Whether or not copyrighted works are used in media classes	有／Yes
その他／Others	〇I will use Teams to communicate with you regarding classes, so please install the app. 〇For registration on Teams, please contact Faculty Educational Secretariat. 〇Recording of classes is prohibited.

授業情報／Class Information

基本情報/Basic Information

担当教員情報/Instructor Information